Title: Postdoctoral Fellow - Tumor Immunology and Dendritic Cell Research
Description: We are seeking a Postdoctoral Fellow to join the Carbone Lab and contribute to novel research in tumor immunology, with a particular focus on dendritic cells (DCs) and their role in shaping immune responses in cancer. This position offers the opportunity to work on high-impact research projects, including the use of innovative tools like the STAMP model (Skin Tumor Array by Micro-poration) (PMID: 37258670), which enables non-invasive, high-throughput monitoring of immune cell recruitment and interactions in tumors. The fellow will have the chance to contribute to translational research aimed at developing novel immunotherapies.
This position provides significant opportunities for professional development, offering the ability to lead independent projects while collaborating closely with the Principal Investigator (PI) and other lab members. As part of our growing team, the postdoctoral fellow will play a key role in advancing the lab's research agenda and building a strong research culture.
Job Responsibilities
70% Experimental Research:
- Independently design, plan, and execute experiments focused on tumor immunology, particularly the role of DCs and other immune cells in the tumor microenvironment.
- Utilize advanced experimental techniques, including flow cytometry, live imaging, and in vivo tumor models, to study immune cell recruitment, interaction, and function.
- Contribute to the development of new experimental models and technologies relevant to the lab’s focus on immune regulation and cancer immunotherapy.
- Meticulously document experiments including procedures and experimental records. Process, analyze, and interpret experimental data.
15% Scientific Communication:
- Actively participate in lab meetings, provide scientific insights, and contribute to group project design and development.
- Prepare and contribute to research publications, grants, reports, and presentations.
- Present research findings at conferences and seminars to share lab achievements and gather feedback.
15% Mentorship & Lab Operations:
- Mentor and support junior lab members, providing guidance on experimental techniques and scientific methodology.
- Collaborate with fellow researchers in the lab and across departments, fostering a highly interactive and productive research environment.
- Contribute to building a positive and collaborative lab culture, promoting open communication and shared success.
- Assist in maintaining the day-to-day operations of the lab, including overseeing supply management, ensuring compliance with safety regulations, and maintaining key lab equipment.
- Collaborate with lab management in organizing and maintaining the animal colony for in vivo studies.
Experimental Methods
- Flow cytometry for immune profiling
- In vivo tumor models and animal handling (including tumor implantation, injections, etc)
- Advanced microscopy for live imaging of tumor-immune interactions
- Tissue harvest and processing
- Cell culture, including primary immune cells
- Cell engineering, including plasmid design and CRISPR techniques
- Computational image and data analysis (e.g., Python, ImageJ)
Required Education and Experience
Doctorate degree (PhD/DVM/MD) in specialty area from an accredited university training program.
Experience using basic research techniques of specialty area.
Required Credentials
N/A.
Preferred
- Expertise in cancer biology, immunotherapy mechanisms, and the role of dendritic cells in tumor environments.
- Excellent organizational skills with the ability to manage multiple projects, maintain accurate records, and work collaboratively.
- Proven ability to publish in peer-reviewed journals and present at scientific conferences.
- Experience mentoring junior scientists and fostering a collaborative, supportive lab culture.
- Strong publication record in tumor immunology, immune microenvironments, dendritic cells, or cancer immunotherapy.
- Proficiency in microscopy techniques, including live imaging.
- Expertise in immune cell characterization, tissue processing, and performing in vitro immunoassays.
- Experience with preclinical tumor models and conducting in vivo immunology studies.
- Experience in computational data analysis, including basic coding (e.g., Python) and proficiency with tools like FlowJo or ImageJ.
Compensation Range
$65,478.00 - $98,571.00 per year
Salary Information
This compensation range was calculated based on full-time employment (2080 hours worked per calendar year). Offers are determined by multiple factors including equity, skills, experience, and expertise, and may vary within the range provided.
Disclaimer for Out of State Applicants
This compensation range is specific to Seattle, positions located outside of Seattle may be compensated differently depending on various factors.
Benefits Information
Seattle Children’s offers a generous benefit package, including medical, dental, and vision plans, 403(b), life insurance, paid time off, tuition reimbursement, and more. Additional details on our benefits can be found on our website www.seattlechildrens.org/careers/benefits.
About Us
Hope. Care. Cure. These three simple words capture what we do at Seattle Children’s – to help every child live the healthiest and most fulfilling life possible. Are you ready to engage with a mission-driven organization that is life-changing to many, and touches the hearts of all? #HOPECARECURE
Our founding promise to the community is as valid today as it was over a century ago: we will care for all children in our region, regardless of the families’ ability to pay. Together, we deliver superior patient care, advance new discoveries and treatments through pediatric research, and serve as the pediatric and adolescent, academic medical center for Washington, Alaska, Montana and Idaho – the largest region of any children’s hospital in the country.
In 2022, U.S. News & World Report once again ranked Seattle Children’s among the nation’s best children’s hospitals – for the 30th year in a row. For more than a decade, Seattle Children’s has been nationally ranked in all 10 specialty areas evaluated by U.S. News & World Report. We are honored to be the top-ranked pediatric hospital in Washington and the Pacific Northwest.
As a Magnet designated institution, and classified among America’s best large employers by Forbes, we recognize the importance of hiring and developing great talent to provide best-in-class care to the patients and families we serve. Our organizational DNA takes form in our core values: Compassion, Excellence, Integrity, Collaboration, Equity and Innovation. Whether it’s delivering frontline care to our patients in a kind and caring manner, practicing the highest standards of quality and safety, or being relentlessly curious as we work towards eradicating childhood diseases, these values are the fabric of our culture and community. The future starts here.
Our Commitment to Diversity
Our community welcomes diverse experiences, backgrounds, and thoughts as this is what drives our spirit of inquiry and allows us to better connect with our increasingly diverse patients and families. Our organization recruits, employs, trains, compensates, and promotes without regard to race, religion, color, national origin, gender (including pregnancy, childbirth, or related medical conditions), sexual orientation, gender identity, gender expression, age, status as a protected veteran, status as an individual with a disability, or other applicable legally protected characteristics.
The people who work at Seattle Children’s are members of a community that seeks to respect and celebrate all the qualities that make each of us unique. Each of us is empowered to be ourselves within this community, which cultivates and promotes equity, diversity, and inclusion at all levels.
Seattle Children’s is proud to be an Equal Opportunity Workplace and Affirmative Action Employer.
